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REVIEW ARTICLE
Year : 2019  |  Volume : 5  |  Issue : 1  |  Page : 3-6

Probiotic supplementation and reducing infiammation in hemodialysis patients: A systematic review


1 Dietician, Department of Food and Nutrition, Covenant Healthcare, Mount Pleasant, Michigan, USA
2 Dietician, Department of Food and Nutrition, Central Michigan University, Mount Pleasant, Michigan, USA

Correspondence Address:
Dr. Kirsten N Abney
Central Michigan University, 1200 S., Franklin Street, Mount Pleasant 48859, Michigan
USA
Susan J Hewlings
Central Michigan University, 1200 S., Franklin Street, Mount Pleasant 48859, Michigan
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jrnm.jrnm_16_19

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Background: Chronic kidney disease (CKD) is a growing health problem worldwide. Uremic toxin buildup caused by protein bacterial metabolites such as indoleamines, urea, and indoxyl sulfate contribute to dysbiosis in the gut microbiome in hemodialysis patients, which contributes to a pro-infiammatory environment. Aims: This systematic review of the literature considers the confiicting evidence on probiotic supplementation and infiammatory status in CKD patients receiving hemodialysis. Methods: PubMed, EBSCO, and Google Scholar were all used to search for control/clinical trials demonstrating the effects of probiotic supplementation on these protein bacterial metabolites and C-reactive protein (CRP) levels. Results: Four of the five studies observed no significant findings in the reduction of infiammatory status in this population. One study demonstrated a significant reduction in CRP levels after 3 months of probiotic supplementation. Many articles varied between using single and multiple strains of bacteria which contributed to limitations to the studies. There was limited supporting evidence to suggest that probiotic supplementation could reduce infiammatory status in hemodialysis patients. Conclusions: Based on the findings, more research is needed before any conclusive recommendations can be made on whether probiotic supplementation would be beneficial for patients receiving hemodialysis treatments.


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