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CLASSROOM READING
Year : 2019  |  Volume : 5  |  Issue : 2  |  Page : 48-50

Uremic toxins, oxidative stress, and inflammation in chronic kidney disease


Department of Nephrology, Virinchi Hospital, Hyderabad, Telangana, India

Correspondence Address:
Dr. Ratan Jha
Department of Nephrology, Virinchi Hospital, Hyderabad, Telangana
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jrnm.jrnm_57_19

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Chronic kidney disease (CKD) is a state of exaggerated oxidative stress and chronic inflammation. The syndrome of CKD culminates in three spheres of dysfunction namely: accumulation of uremic toxins, oxidative stress and progressive systemic inflammation. It is postulated that uremic as well as non-uremic solutes may play an important role in worsening oxidative stress and activating many other inimical pathways which results in endothelial dysfunction and cytokine driven inflammatory process. This article briefly touches upon biomarkers and treatment strategies targeting uremia, oxidative stress and inflammation.


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