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MINI REVIEW
Year : 2020  |  Volume : 6  |  Issue : 3  |  Page : 47-50

Licorice plant extract: Does it hold a promise for coronavirus disease-2019


1 Navin Upchar Kendra; Pratibha Complex Buxipur, Gorakhpur, Uttar Pradesh, India
2 Sundaram Arulrhaj Hospitals, Tutiporin, Tamil Nadu, India

Correspondence Address:
Dr. Vivek Chandra
Navin Upchar Kendra 2, Pratibha Complex Buxipur, Gorakhpur - 273 001, Uttar Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jrnm.jrnm_26_20

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Coronavirus (CoV) disease 2019 (COVID-19) is defined as illness caused by a novel CoV first identified amid an outbreak of respiratory illness cases in Wuhan, China. Data provided by the World Health Organization Health Emergency Dashboard (September 16, 2020) reports 29,444,198 confirmed cases worldwide since the beginning of the epidemic of which 931,321 cases have been fatal. No drugs or biologics have proven to be 100% effective for the prevention or treatment of COVID-19 so far. Glycyrrhizin (GL) is one of the major compounds isolated from the roots of licorice. Many studies have confirmed the antiviral activity of GL. GL is an effective antiviral compound against hepatitis C virus, HIV, CVB3, DHV, EV71, CVA16, HSV, and H5N1 by weakening virus activity, such as inhibiting virus gene expression and replication, reducing adhesion force and stress, and reducing HMGB1 binding to DNA. The primary areas of concern are the regulation of dosage, hypokalemia, toxicity, drug interactions, routes of administration, and blood pressure management. Does licorice needs more studies on COVID-19 patients to demonstrate its merit and does licorice have some promise as an adjuvant if not cure for COVID-19 pandemic.


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